[R] survival analysis with right and left censoring and	time-dependent covariates
    Berta 
    ibanez at bioef.org
       
    Wed May  3 13:46:29 CEST 2006
    
    
  
Hi R-users,
I have a data set with a particular type of interval-censored data: right 
and left censored data, but no other type of interval censoring. I need to 
fit a model with covariates to evaluate the influence of them on the 
survival time.
First: I use Surv of library(survival) to create my survival object. I have 
two possibilities:
                                      Surv(c(1,1,NA,3),c(1,NA,2,3),type="interval2")
                                       # 1  1+   2-   3 , I do not [a,b] in 
any case.
                                       Surv(c(1,1,2,3),c(1,2,2,3),c(1,0,2,1),type="interval")
                                          1   1+  2-   3
Second:Given that coxph is not valid for interval-censored type of data, I 
use survreg with covariates. 
survreg(Surv(c(1,1,NA,3),c(1,NA,2,3),type="interval2")  ~covariate)
Third: Now I need to fit a model with time-dependent covariates, but I only 
find examples of how to include time-dependent covariates when using coxph 
without left censoring (data=Rossi.txt,  Jhon Fox), and therfore the "event" 
in Surv is 0 until the event occurrs:
http://cran.r-project.org/doc/contrib/Fox-Companion/appendix-cox-regression.pdf
My question is: How could I fit a survival model that include right-left 
censoring and time-dependent covariates?
Thanks a lot in advance,
Berta.
    
    
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